Neuropathological Diagnosis of Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Neuropathological alterations in Alzheimer disease.
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. Despite their inherently cross-sectional nature, postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies...
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Variant Alzheimer disease (varAD) is clinically characterized by the combination of presenile dementia with spastic paraparesis and is caused by certain mutations of the presenilin 1 (PS-1) gene. We now present the unusual neuropathological phenotype of varAD as seen in 5 affected members of the original Finnish family with a genomic deletion encompassing exon 9 of the PS-1 gene. Their primary ...
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WHAT DID THESE RESEARCHERS STUDY? These researchers were interested in the idea of “cognitive reserve”—the brain’s ability to resist harm from disease. They studied the specific example of Alzheimer disease (AD), and the idea that people with more cognitive reserve might be able to continue to function fairly well even as the disease advances. To do this, they studied people before they develop...
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Microglia have long been noted to be present and activated in Alzheimer brain. Demonstrations that these microglia are associated with the specific lesions of Alzheimer disease-Aβ plaques and neurofibrillary tangles-and that these microglia overexpress the potent proinflammatory cytokine interleukin-1 led to the recognition of a potential pathogenic role for these cells in initiation and progre...
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BACKGROUND Alzheimer disease is an increasingly common condition in older people. Knowledge of life expectancy after the diagnosis of Alzheimer disease and of associations of patient characteristics with survival may help planning for future care. OBJECTIVE To investigate the course of Alzheimer disease after initial diagnosis and examine associations hypothesized to correlate with survival a...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1990
ISSN: 0022-3069
DOI: 10.1097/00005072-199009000-00010